Use case

Sleep

Which peptides have human evidence for sleep claims?

Context

Sleep claims belong next to CBT-I, sleep-hygiene measures, and approved hypnotics; peptide marketing rarely engages that comparison.

Compare DSIP, epitalon, pinealon, and selank for sleep: where the human literature is old, small, and inconsistent, and community schedules are built on premise rather than trials.

Peptides compared

Limited human evidence

DSIP

A sleep-associated nonapeptide with older human insomnia studies, unresolved biology, and modern emideltide/DSIP claims that need careful source-by-source reading.

Investigational / not approved

Mostly preclinical

Epitalon

A short AEDG tetrapeptide discussed in circadian, melatonin, telomere, retina, and longevity contexts, where public claims often exceed direct clinical evidence.

Investigational / not approved

Mostly preclinical

Pinealon

A short EDR tripeptide discussed for neuroprotection, cognition, and sleep-adjacent claims, with support still concentrated in reviews, preclinical work, and unresolved source questions.

Investigational / not approved

Limited human evidence

Selank is a Russian-developed intranasal anxiolytic peptide with small domestic trials behind it. Outside that literature, controlled evidence is sparse and vendor-modified analogs muddy the category.

Not FDA-approved for listed uses

Sources

1.
PubMed. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study 1992.
PMID:1299794 Accessed 2026-06-08.
Older human insomnia study; keep study context separate from protocol advice.
2.
PubMed. Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs 1987.
PMID:3583493 Accessed 2026-06-08.
Older human sleep source; not a public dosing/protocol basis.
3.
PubMed. Delta sleep-inducing peptide (DSIP): a still unresolved riddle 2006.
PMID:16539679 Accessed 2026-06-08.
Review emphasizing unresolved DSIP biology.
4.
PubMed. Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people 2007.
PMID:17969590 Accessed 2026-06-09.
Older human and non-human primate melatonin-rhythm source naming Epitalon/AEDG; biomarker context, not sleep efficacy or use guidance.
5.
PubMed. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease 2020.
doi:10.3390/molecules26010159 PMID:33396470 Accessed 2026-06-08.
Review of Glu-Asp-Arg/EDR mechanisms and neuroprotection claims; useful for mechanism mapping, not a sleep protocol source.
6.
FDA. July 23-24, 2026: Meeting of the Pharmacy Compounding Advisory Committee 2026.
Accessed 2026-07-24.
FDA meeting page for the July 23-24, 2026 PCAC review of BPC-157, KPV, TB-500, MOTs-C, emideltide/DSIP, Semax, and Epitalon bulk substances, including the uses evaluated for each, briefing documents, and docket FDA-2025-N-6895.